microRNA target identification by transcriptomics

miRNAtarget

miRNAtarget is a software tool under continuous development for the analysis of the targets of differentially expressed miRNAs.

To perform miRNA-target analyses please signup and purchase a plan that is optimal for your purposes.

Papers published so far on the utilization and validation of the miRNAtarget software

Our team published multiple articles on the utilization and experimental validation of the predictions assessed by the miRNAtarget software:

  1. Schreckenberg R, Klein J, Kutsche HS, Schulz R, Gömöri K, Bencsik P, Benczik B, Ágg B, Sághy É, Ferdinandy P, Schlüter KD.
    Ischaemic Post-Conditioning in Rats: Responder and Non-Responder Differ in Transcriptome of Mitochondrial Proteins.
    J Cell Mol Med. 2020 May;24(10):5528-5541.
  2. Sághy É, Vörös I, Ágg B, Kiss B, Koncsos G, Varga ZV, Görbe A, Giricz Z, Schulz R, Ferdinandy P.
    Cardiac miRNA Expression and Their mRNA Targets in a Rat Model of Prediabetes.
    Int J Mol Sci. 2020 Mar 20;21(6):2128.
  3. Bencsik P, Kiss K, Ágg B, Baán JA, Ágoston G, Varga A, Gömöri K, Mendler L, Faragó N, Zvara Á, Sántha P, Puskás LG, Jancsó G, Ferdinandy P.
    Sensory Neuropathy Affects Cardiac miRNA Expression Network Targeting IGF-1, SLC2a-12, EIF-4e, and ULK-2 mRNAs.
    Int J Mol Sci. 2019 Feb 25;20(4):991.
  4. Ágg B, Baranyai T, Makkos A, Vető B, Faragó N, Zvara Á, Giricz Z, Veres DV, Csermely P, Arányi T, Puskás LG, Varga ZV, Ferdinandy P.
    MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium.
    Sci Rep. 2018 Jul 4;8(1):10134.

Developed by

miRNAtarget was developed in the collaboration of the Pharmahungary Group and the Department of Pharmacology and Pharmacotherapy, Semmelweis University.

Supported by

This study was supported by the National Research, Development and Innovation Office of Hungary (NKFIA; National Heart Program NVKP-16-1-2016-0017).

Contact

If you need technical support please contact [email protected].

Terms and Conditions

Please read Terms and Conditions of the miRNAtarget service.

miRNAtarget features

Aims

  • to analyze the targets of miRNAs from a network theoretical perspective
  • to predict the most probable targets of differentially expressed miRNAs

Advantages

  • miRNAtarget relies on multiple miRNA-target interaction databases
  • simple and powerful network theoretical approach to identify the most probable targets of differentially expressed miRNAs
  • increased coverage of possible miRNA-target interactions compared to experimentally validated databases
  • higher accuracy than available predicted miRNA-target interaction databases
  • interactions predicted by miRNAtarget has been successfully validated in two animal studies (submitted for publication)

Recommended for

  • basic researchers
  • small biotech companies
  • pharmaceutical industry